Sofosbuvir

J - Antiinfectives For Systemic Use -> J05 - Antivirals For Systemic Use -> J05A - Direct Acting Antivirals -> J05AX - Other Antivirals -> J05AX15 - Sofosbuvir
Administration category: Free Medicine group: antiviral Brand name: Sovaldi

Standard dosages

≥ 18 years
WeightROALoadDosage
ROA:
po
Load:
-
Dosage:
400mg 1 dd

Kidney function

≥ 18 years
ROAGFRDosageIntervalComments
ROA: po
GFR:
30 - 50
Dosage:
geen aanpassing
GFR:
<30
Dosage:
geen gegevens beschikbaar
Renal elimination: 80%
Dosage: dependent on kidney function

Renal function-replacement therapy

CAPD: geen gegevens bekend

Hemo dialysis: geen gegevens bekend

Interactions

Interaction with (ATC): Interaction with: Expected effect:
Interaction with (ATC):
C01BD01 - Amiodarone
Interaction with:
Expected effect:
indien gecombineerd met daclatasvir: ernstige bradycardie en AV-blokkade
Interaction with (ATC):
Interaction with:
niet gelijktijdig toedienen met krachtige inductoren van Pgp of BCRP zoals rifampicine, rifabutine, carbamazepine, oxcarbazepine, fenytoïne, fenobarbital, en sint-janskruid.
Expected effect:
verlaging bloedspiegel

Pregnancy

Due to the expiration of the alphanumeric classification for use in pregnancy and lactation, reference is made to the current, online information of the Teratology Information Service (TIS) of LAREB:

For individual advice, consult an expert on site.
Metadata

Swab vid: M-287563.1
Updated: 06/16/2019 - 20:05
Status: Published

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